|
KMID : 0367320080190010019
|
|
Journal of the Korean Academy of Child and Adolescent Psychiatry
2008 Volume.19 No. 1 p.19 ~ p.27
|
|
|
Dopamine Transporter Gene and Dopamine D2, D3, D4 Receptor Gene Polymorphisms in Attention Deficit Hyperactivity Disorder
|
|
Park Pil-Sang
Kim Dae-Kwang
Jung Chul-Ho
|
|
|
Abstract
|
|
|
Objectives:The aim of this study was to examine the association of attention-deficit hyperactivity disorder (ADHD) in Korean populations with functional polymorphisms of six genes dopamine receptors (Ser311/Cys311 polymorphism, Taq1 A polymorphism, and Taq1 B polymorphism in DRD2, BalI polymorphism in DRD3, and promoter -521 C/T polymorphism and exon III 48 bp repeat polymorphism in DRD4) and one gene in dopamine transporter (DAT1).
Methods:Participants were 58 children with ADHD and 110 control children. The genotypes were determined by PCR.
Results:There was a statistically significant difference in genotype frequency of -521 C/T polymorphism within the promoter region of the DRD4 between two groups. Furthermore, in the male group, both genotype and allele frequencies showed statistically significant differences.
Conclusion:Findings of the study indicate that -521 C/T polymorphism in promoter region of DRD4 appears to be a possible candidate gene for ADHD in Korean population.
|
|
|
KEYWORD
|
|
|
ADHD, Dopamine Transporter Gene, Dopamine Receptor Gene
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|